Intel Xeon E3 1280 's Advantages
Higher base frequency (3.5GHz vs 2.1GHz)
Lower TDP (95W vs 135W)
Intel Xeon E5 4669 v3 's Advantages
Released 4 years and 2 months late
Higher specification of memory (2133 vs 3)
Larger L3 cache size (45MB vs 8MB)
More modern manufacturing process (22nm vs 32nm)