Opteron 1381 's Advantages
Higher base frequency (2.5GHz vs 2.25GHz)
Lower TDP (115W vs 500W)
AMD EPYC 9965 's Advantages
Released 15 years and 4 months late
Higher specification of memory (6000 vs 1333)
Newer PCIe version (5 vs 2)
Larger L3 cache size (384MB vs 6MB)
More modern manufacturing process (3nm vs 45nm)