Opteron 1389 's Advantages
Higher base frequency (2.9GHz vs 2.1GHz)
Lower TDP (115W vs 170W)
AMD EPYC 7281 's Advantages
Released 8 years late
Higher specification of memory (2666 vs 1333)
Newer PCIe version (3 vs 2)
Larger L3 cache size (32MB vs 6MB)
More modern manufacturing process (14nm vs 45nm)