Opteron 2216 HE (F3) 's Advantages
Lower TDP (68W vs 180W)
AMD EPYC 7502P 's Advantages
Released 13 years late
Higher specification of memory (3200 vs 2)
Newer PCIe version (4 vs 1)
Higher base frequency (2.5GHz vs 2.4GHz)
More modern manufacturing process (7nm vs 90nm)