Opteron 2216 HE (F3) 's Advantages
Higher base frequency (2.4GHz vs 2.3GHz)
Lower TDP (68W vs 99W)
Opteron 6338P 's Advantages
Released 7 years and 5 months late
Higher specification of memory (1600 vs 2)
Newer PCIe version (2 vs 1)
More modern manufacturing process (32nm vs 90nm)