Opteron 2220 's Advantages
Lower TDP (95W vs 280W)
AMD Ryzen Threadripper PRO 5965WX 's Advantages
Released 15 years and 1 months late
Higher specification of memory (3200 vs 2)
Newer PCIe version (4 vs 1)
Higher base frequency (3.8GHz vs 2.8GHz)
More modern manufacturing process (7nm vs 90nm)