Opteron 2222 SE 's Advantages
Higher base frequency (3GHz vs 2.2GHz)
Lower TDP (119W vs 155W)
AMD EPYC 7452 's Advantages
Released 12 years and 4 months late
Higher specification of memory (3200 vs 2)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)