Opteron 2222 SE 's Advantages
Higher base frequency (3GHz vs 2.8GHz)
Lower TDP (119W vs 140W)
Opteron 6386 SE 's Advantages
Released 5 years and 7 months late
Higher specification of memory (1600 vs 2)
Newer PCIe version (2 vs 1)
More modern manufacturing process (32nm vs 90nm)