Opteron 3380 's Advantages
Higher base frequency (2.6GHz vs 2.2GHz)
Lower TDP (65W vs 170W)
AMD EPYC 7301 's Advantages
Released 4 years and 6 months late
Higher specification of memory (2666 vs 3)
Newer PCIe version (3 vs 2)
Larger L3 cache size (64MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)