Opteron 3380 's Advantages
Higher base frequency (2.6GHz vs 2GHz)
Lower TDP (65W vs 165W)
Intel Xeon Silver 4416 's Advantages
Released 10 years and 1 months late
Higher specification of memory (4000 vs 3)
Newer PCIe version (5 vs 2)
Larger L3 cache size (37.5MB vs 8MB)
More modern manufacturing process (10nm vs 32nm)