Opteron 6180 SE 's Advantages
Higher base frequency (2.5GHz vs 2.3GHz)
Lower TDP (140W vs 320W)
AMD EPYC 9645 's Advantages
Released 13 years and 8 months late
Higher specification of memory (6000 vs 1333)
Newer PCIe version (5 vs 2)
Larger L3 cache size (256MB vs 12MB)
More modern manufacturing process (3nm vs 45nm)