Opteron 6180 SE 's Advantages
Released 4 years late
Higher specification of memory (1333 vs 2)
Newer PCIe version (2 vs 1)
More modern manufacturing process (45nm vs 90nm)
Opteron 2220 's Advantages
Higher base frequency (2.8GHz vs 2.5GHz)
Lower TDP (95W vs 140W)