Opteron 6272 's Advantages
Lower TDP (115W vs 200W)
AMD EPYC 7443 's Advantages
Released 9 years and 4 months late
Higher specification of memory (3200 vs 3)
Newer PCIe version (4 vs 2)
Higher base frequency (2.85GHz vs 2.1GHz)
Larger L3 cache size (128MB vs 16MB)
More modern manufacturing process (7nm vs 32nm)