Opteron 6278 's Advantages
Lower TDP (115W vs 130W)
AMD EPYC 7303 's Advantages
Released 11 years and 4 months late
Higher specification of memory (DDR4-3200 vs DDR3)
Newer PCIe version (4 vs 2)
Larger L3 cache size (64MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)