Opteron 6278 's Advantages
Lower TDP (115W vs 180W)
AMD EPYC 7413 's Advantages
Released 8 years and 10 months late
Higher specification of memory (3200 vs 3)
Newer PCIe version (4 vs 2)
Higher base frequency (2.65GHz vs 2.4GHz)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)