Opteron 6278 's Advantages
Lower TDP (115W vs 210W)
AMD EPYC 9335 's Advantages
Released 12 years and 5 months late
Higher specification of memory (6000 vs 3)
Newer PCIe version (5 vs 2)
Higher base frequency (3GHz vs 2.4GHz)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (4nm vs 32nm)