Opteron 6278 's Advantages
Lower TDP (115W vs 300W)
AMD EPYC 9365 's Advantages
Released 12 years and 5 months late
Higher specification of memory (6000 vs 3)
Newer PCIe version (5 vs 2)
Higher base frequency (3.4GHz vs 2.4GHz)
Larger L3 cache size (192MB vs 8MB)
More modern manufacturing process (4nm vs 32nm)