Opteron 6278 's Advantages
Lower TDP (115W vs 400W)
AMD EPYC 9565 's Advantages
Released 12 years and 5 months late
Higher specification of memory (6000 vs 3)
Newer PCIe version (5 vs 2)
Higher base frequency (3.15GHz vs 2.4GHz)
Larger L3 cache size (384MB vs 8MB)
More modern manufacturing process (4nm vs 32nm)