Opteron 6278 's Advantages
Higher base frequency (2.4GHz vs 2.1GHz)
Lower TDP (115W vs 270W)
Intel Xeon Platinum 8454H 's Advantages
Released 10 years and 8 months late
Higher specification of memory (4800 vs 3)
Newer PCIe version (5 vs 2)
Larger L3 cache size (82.5MB vs 8MB)
More modern manufacturing process (10nm vs 32nm)