Opteron 6376 's Advantages
Lower TDP (115W vs 290W)
AMD EPYC 9454P 's Advantages
Released 10 years late
Higher specification of memory (DDR5-4800 vs DDR3)
Newer PCIe version (5 vs 2)
Higher base frequency (2.75GHz vs 2.3GHz)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)