Opteron 6376 's Advantages
Higher base frequency (2.3GHz vs 2.25GHz)
Lower TDP (115W vs 360W)
AMD EPYC 9754 's Advantages
Released 10 years and 7 months late
Higher specification of memory (4800 vs 1866)
Newer PCIe version (5 vs 2)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)