Opteron 6378 's Advantages
Lower TDP (115W vs 240W)
AMD EPYC 7F72 's Advantages
Released 7 years and 5 months late
Higher specification of memory (3200 vs 1866)
Newer PCIe version (4 vs 2)
Higher base frequency (3.2GHz vs 2.4GHz)
Larger L3 cache size (192MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)