Opteron 6378 's Advantages
Lower TDP (115W vs 320W)
AMD EPYC 9375F 's Advantages
Released 11 years and 11 months late
Higher specification of memory (6000 vs 1866)
Newer PCIe version (5 vs 2)
Higher base frequency (3.85GHz vs 2.4GHz)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (4nm vs 32nm)