Opteron 8216 (F3) 's Advantages
Higher base frequency (2.4GHz vs 2.2GHz)
Lower TDP (95W vs 155W)
AMD EPYC 7452 's Advantages
Released 13 years late
Higher specification of memory (3200 vs 667)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)