Opteron 8220 SE (F3) 's Advantages
Higher base frequency (2.8GHz vs 2.45GHz)
Lower TDP (120W vs 280W)
AMD EPYC 7763 's Advantages
Released 14 years and 7 months late
Higher specification of memory (3200 vs 667)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)