Opteron 8220 's Advantages
Higher base frequency (2.8GHz vs 2.25GHz)
Lower TDP (95W vs 360W)
AMD EPYC 9754 's Advantages
Released 16 years and 4 months late
Higher specification of memory (4800 vs 667)
Newer PCIe version (5 vs 1)
More modern manufacturing process (5nm vs 90nm)