Opteron 8220 's Advantages
Higher base frequency (2.8GHz vs 1.7GHz)
Lower TDP (95W vs 105W)
Intel Xeon E5 4648 v3 's Advantages
Released 8 years and 4 months late
Higher specification of memory (1866 vs 667)
Newer PCIe version (3 vs 1)
More modern manufacturing process (22nm vs 90nm)