Xeon E 2486 's Advantages
Higher base frequency (3.5GHz vs 2.2GHz)
Lower TDP (95W vs 330W)
Xeon 6780E 's Advantages
Released 6 months late
Higher specification of memory (6400 vs 4800)
Larger L3 cache size (108MB vs 18MB)
More modern manufacturing process (5nm vs 10nm)