AMD EPYC 7251 's Advantages
Lower TDP (120W vs 320W)
AMD EPYC 9645 's Advantages
Released 7 years and 4 months late
Higher specification of memory (6000 vs 2400)
Newer PCIe version (5 vs 3)
Higher base frequency (2.3GHz vs 2.1GHz)
Larger L3 cache size (256MB vs 32MB)
More modern manufacturing process (3nm vs 14nm)