AMD EPYC 7643 's Advantages
Released 8 years and 4 months late
Higher specification of memory (3200 vs 1866)
Newer PCIe version (4 vs 2)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)
Opteron 6380 's Advantages
Higher base frequency (2.5GHz vs 2.3GHz)
Lower TDP (115W vs 225W)