Intel Xeon E3 1280 v5 's Advantages
Higher base frequency (3.7GHz vs 3.2GHz)
Lower TDP (80W vs 95W)
Xeon E 2488 's Advantages
Released 8 years and 2 months late
Higher specification of memory (4800 vs 4)
Newer PCIe version (5 vs 3)
Larger L3 cache size (24MB vs 8MB)
More modern manufacturing process (10nm vs 14nm)