Intel Xeon E3 1280 's Advantages
Higher base frequency (3.5GHz vs 2.85GHz)
Lower TDP (95W vs 200W)
AMD EPYC 7443 's Advantages
Released 9 years and 11 months late
Higher specification of memory (3200 vs 3)
Newer PCIe version (4 vs 3)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)