Intel Xeon E5 4640 's Advantages
Higher base frequency (2.4GHz vs 2.2GHz)
Lower TDP (95W vs 330W)
Xeon 6780E 's Advantages
Released 12 years and 1 months late
Higher specification of memory (6400 vs 3)
Newer PCIe version (5 vs 3)
Larger L3 cache size (108MB vs 20MB)
More modern manufacturing process (5nm vs 32nm)