Intel Xeon E5 4650 's Advantages
Higher base frequency (2.7GHz vs 1.9GHz)
Lower TDP (130W vs 350W)
Intel Xeon w9 3495X 's Advantages
Released 10 years and 9 months late
Higher specification of memory (4800 vs 3)
Newer PCIe version (5 vs 3)
Larger L3 cache size (105MB vs 20MB)
More modern manufacturing process (10nm vs 32nm)