Intel Xeon Gold 6421N 's Advantages
Released 8 years and 4 months late
Higher specification of memory (DDR5-4400 vs DDR3)
Newer PCIe version (5 vs 3)
Larger L3 cache size (60MB vs 25MB)
More modern manufacturing process (10nm vs 22nm)
Intel Xeon E5 2649 v3 's Advantages
Higher base frequency (2.3GHz vs 1.8GHz)
Lower TDP (105W vs 185W)