Opteron 2220 's Advantages
Higher base frequency (2.8GHz vs 2.1GHz)
Lower TDP (95W vs 390W)
AMD EPYC 9845 's Advantages
Released 17 years and 8 months late
Higher specification of memory (6000 vs 2)
Newer PCIe version (5 vs 1)
More modern manufacturing process (3nm vs 90nm)