Opteron 2220 's Advantages
Higher base frequency (2.8GHz vs 2.6GHz)
Intel Xeon E 2378 's Advantages
Released 14 years and 7 months late
Higher specification of memory (3200 vs 2)
Newer PCIe version (4 vs 1)
More modern manufacturing process (14nm vs 90nm)
Lower TDP (65W vs 95W)