Opteron 2220 's Advantages
Higher base frequency (2.8GHz vs 1.8GHz)
Intel Xeon E5 2648L 's Advantages
Released 5 years and 1 months late
Higher specification of memory (3 vs 2)
Newer PCIe version (3 vs 1)
More modern manufacturing process (32nm vs 90nm)
Lower TDP (70W vs 95W)