Opteron 2220 's Advantages
Higher base frequency (2.8GHz vs 2.1GHz)
Lower TDP (95W vs 270W)
Intel Xeon Gold 6538N 's Advantages
Released 16 years and 10 months late
Higher specification of memory (5200 vs 2)
Newer PCIe version (5 vs 1)
More modern manufacturing process (10nm vs 90nm)