Opteron 2220 's Advantages
Higher base frequency (2.8GHz vs 2GHz)
Lower TDP (95W vs 250W)
Xeon 6746E 's Advantages
Released 17 years and 4 months late
Higher specification of memory (5600 vs 2)
Newer PCIe version (5 vs 1)
More modern manufacturing process (5nm vs 90nm)