Opteron 2220 's Advantages
Higher base frequency (2.8GHz vs 2.2GHz)
Lower TDP (95W vs 330W)
Xeon 6780E 's Advantages
Released 17 years and 4 months late
Higher specification of memory (6400 vs 2)
Newer PCIe version (5 vs 1)
More modern manufacturing process (5nm vs 90nm)