Opteron 4376 HE 's Advantages
Lower TDP (65W vs 280W)
AMD EPYC 9354 's Advantages
Released 9 years and 11 months late
Higher specification of memory (4800 vs 3)
Higher base frequency (3.25GHz vs 2.6GHz)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)