Opteron 4376 HE 's Advantages
Lower TDP (65W vs 280W)
AMD Ryzen Threadripper PRO 5965WX 's Advantages
Released 9 years and 3 months late
Higher specification of memory (3200 vs 3)
Higher base frequency (3.8GHz vs 2.6GHz)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)