Opteron 4376 HE 's Advantages
Higher base frequency (2.6GHz vs 2.2GHz)
Lower TDP (65W vs 125W)
Xeon Platinum 8253 's Advantages
Released 6 years late
Higher specification of memory (4 vs 3)
Larger L3 cache size (22MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)