Opteron 4386 's Advantages
Higher base frequency (3.1GHz vs 2.2GHz)
Lower TDP (95W vs 155W)
AMD EPYC 7452 's Advantages
Released 6 years and 8 months late
Higher specification of memory (3200 vs 3)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)