Opteron 6366 HE 's Advantages
Lower TDP (85W vs 280W)
AMD EPYC 7H12 's Advantages
Released 6 years and 10 months late
Higher specification of memory (3200 vs 1866)
Newer PCIe version (4 vs 2)
Higher base frequency (2.6GHz vs 1.8GHz)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)