Opteron 6378 's Advantages
Higher base frequency (2.4GHz vs 2.1GHz)
Lower TDP (115W vs 250W)
Intel Xeon Platinum 9221 's Advantages
Released 6 years and 5 months late
Higher specification of memory (2933 vs 1866)
Newer PCIe version (3 vs 2)
Larger L3 cache size (71.5MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)