Opteron 6380 's Advantages
Higher base frequency (2.5GHz vs 1.9GHz)
Lower TDP (115W vs 350W)
Intel Xeon w9 3495X 's Advantages
Released 10 years and 3 months late
Higher specification of memory (4800 vs 1866)
Newer PCIe version (5 vs 2)
Larger L3 cache size (105MB vs 8MB)
More modern manufacturing process (10nm vs 32nm)