Opteron 8218 (F2) 's Advantages
Higher base frequency (2.6GHz vs 2.4GHz)
Lower TDP (95W vs 225W)
AMD EPYC 7642 's Advantages
Released 13 years late
Higher specification of memory (3200 vs 667)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)