Xeon E 2456 's Advantages
Released 11 years late
Higher specification of memory (4800 vs 3)
Newer PCIe version (5 vs 2)
Higher base frequency (3.3GHz vs 2.6GHz)
Larger L3 cache size (18MB vs 8MB)
More modern manufacturing process (10nm vs 32nm)
Opteron 3380 's Advantages
Lower TDP (65W vs 80W)